We were evaluating Bitlocker, and ultimately decided to go with Pointsec for our full disk encryption needs. My hope is that eventually all of our laptop computers will be protected by Bitlocker.
Truecrypt is a great program, but it depends on us being able to force our users to save their data to a certain folder. We haven't even been able to get our users in the habit of saving data to their network share rather than their hard disk. If we can't get them to use one folder of our choosing, how could we get them to use another? We decided that the only way to really protect our data is to encrypt the entire drive.
The problem with Bitlocker is that it is dependent on a TPM 1.2 chip, which only started shipping in the first half of 2006. If you don't have that chip, and you want to use bitlocker, then users will have to keep the key on a USB drive. We decided that the most likely place that users will keep their USB drive is in the case with their laptop. Pointsec allows us to encrypt the entire drive, and keep it completely transparent to our users. That transparency will reduce resistance from the users hopefully.